*, corresponding author

1. Amos C. Hung, Chun-Hao Tsai, Ming-Feng Hou, Wen-Lin Chang, Chie-Hong Wang, Yi-Chen Lee, Alice Ko, Stephen Chu-Sung Hu, Fang-Rong Chang, Pei-Wen Hsieh*, Shyng-Shiou F. Yuan*. The synthetic β-nitrostyrene derivative CYT-rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Cancer Lett. 2016, 371:251-261. (SCI) (I.F.: 6.508; R/C=29/229 in ONCOLOGY)
2. Jin-Yuan Ho, Jyh-Haur Chern, Chung-Fan Hsieh, Szu-Ting Liu, Chien-Jou Liu, Ya-Sian Wang, Ta-Wei Kuo, Sheng-Ju Hsu, Ten-Kuang Yeh, Shin-Ru Shih, Pei-Wen Hsieh, Chen-Hsun Chiu, Jim-Tong Horng. In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71. J. Antimicrob. Chemother. 2016, 71:1922-1932. (SCI) (I.F.: 4.715; R/C=27/267 in PHARMACOLOGY & PHARMACY)
3. Chien-Chong Hong, Chih-Chung Lin, Chian-Lang Hong, Zi-Xiang Lin, Meng-Hua Chung, Pei-Wen Hsieh. Analyzer with On-Chip molecularly-imprinted biosensors for electrical detection of propofol in plasma samples. Biosens. Bioelectron. 2016, 86:623-629. (SCI) (I.F.: 9.518; R/C=1/84 in CHEMISTRY, ANALYTICAL)
4. Yu-Li Chen, Tsong-Long Hwang, Huang-Ping Yu, Jia-You Fang, Kowit Yu Chong, Yao-Wen Chang, Chun-Yu Chen, Hsuan-Wu Yang, Wen-Yi Chang, Pei-Wen Hsieh*. Ilex kaushue and its bioactive component 3,5-dicaffeoylquinic acid protected mice from lipopolysaccharide-induced acute lung injury. Sci. Rep. 2016, 6:34243. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES)
5. Chung-Fan Hsieh, Yu-Li Chen, Chwan-Fwu Lin, Jin-Yuan Ho, Chun-Hsun Huang, Cheng-Hsun Chiu, Pei-Wen Hsieh, Jim-Tong Horng. An extract from Taxodium distichum targets hemagglutinin- and neuraminidase-related activities of influenza virus in vitro. Sci. Rep. 2016, 6:36015. (SCI) (I.F.: 4.011; R/C=15/69 in MULTIDISCIPLINARY SCIENCES)
6. Wen-Chin Chiu, Yi-Chen Lee, Yu-Han Su, Yen-Yun Wang, Chun-Hao Tsai, Yi-An Hou, Chie-Hong Wang, Ying-Fong Huang, Chih-Jen Huang, Shah-Hwa Chou, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. The synthetic β-nitrostyrene derivative CYT-Rx20 inhibits esophageal tumor growth and metastasis via PI3K/AKT and STAT3 pathways. PLoS One 2016, 11:e0166453. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES)
7. Chun-Hao Tsai, Pei-Wen Hsieh, Yi-Chen Lee, Chie-Hong Wang, Wen-Chin Chiu, Chun-Wun Lu, Yen-Yun Wang, Stephen Chu-Sung Hu, Tain-Lu Cheng, Shyng-Shiou F. Yuan*. 3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells. Life Sci. 2017, 172:19-26. (SCI) (I.F.: 3.448; R/C= 76/267 in PHARMACOLOGY & PHARMACY)
8. Shun-Chin Yang, Shih-Hsin Chang, Pei-Wen Hsieh, Yin-Ting Huang, Chiu-Ming Ho, Yung-Fong Tsai, Tsong-Long Hwang. Dipeptide HCH6-1 inhibits neutrophil activation and protects against acute lung injury by blocking FPR1. Free Rad. Bio. Med. 2017, 106:254-269. (SCI). (I.F.: 5.657; R/C=43/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
9. Chun-Hao Tsai, Amos C. Hung, Yuan-Yin Chen, Ya-Wen Chiu, Pei-Wen Hsieh, Yi-Chen Lee, Yu-Han Su, Po-Chih Chang, Stephen Chu-Sung Hu, Shyng-Shiou F. Yuan*. 3’-Hydroxy-4’-methoxy-β-methyl-β-nitrostyrene inhibits tumor-igenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. Oncotarget 2017, 8:18106-18117.
10. Pei-Wen Hsieh, Chi-Feng Hung, Chih-Hung Lin, Chang-Wei Huang, Jia-You Fang. Anti-melasma codrug of retinoic acid assists cutaneous absorption with attenuated skin irritation. Eur. J. Pharm. Biopharm. 2017, 114:154-163. (SCI) (I.F.: 4.708; R/C=28/267 in PHARMACOLOGY & PHARMACY)
11. Yen-Yun Wang, Yuk-Kwan Chen, Ya-Ling Hsu, Wen-Chin Chiu, Chun-Hao Tsai, Stephen Chu-Sung Hu, Pei-Wen Hsieh, Shyng-Shiou F. Yuan*. Synthetic β-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Head & Neck 2017, 39:1055-1064. (SCI) (I.F.: 2.442; R/C=10/42 in OTORHINOLARYNGOLOGY)
12. Yen-Yun Wang, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Tsung-Chen Chi, Wan-Ling Huang, Pei-Wen Hsieh, Shyng-Shiou F. Yuan. CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Cancer Chemother. Pharmacol. 2017, 79:1129-1140. (SCI) (I.F.: 3.008; R/C=101/267 in PHARMACOLOGY & PHARMACY)
13. Po-Hsiung Kung, Pei-Wen Hsieh, Ying-Ting Lin, Jia-Hua Lee, I-Hua Chen, Chin-Chung Wu. HPW-RX40 Prevents Human Platelet Activation by Attenuating Cell Surface Protein Disulfide Isomerases. Redo. Biol. 2017, 13:266-277. (SCI) (I.F.: 7.793; R/C=28/298 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
14. Yen-Yun Wang, Pei-Wen Hsieh, Yuk-Kwan Chen, Stephen Chu-Sung Hu, Ya-Ling Hsu, Chun-Hao Tsai, Shyng-Shiou F Yuan. CYT-Rx20 inhibits cervical cancer cell growth and migration through oxidative stress-induced DNA damage, cell apoptosis, and epithelial-to-mesenchymal transition inhibition. Int. J. Gynecol. Cancer 2017, 27:1306-1317. (SCI) (I.F.: 1.764; R/C=52/83 in OBSTETRICS & GYNECOLOGY)
15. Yu-Li Chen, Tsong-Long Hwang, Jia-You Fang, Yu-Hsuan Lan, Kowit Yu Chong, Pei-Wen Hsieh*. Polysaccharides from Kochia scoparia fruits protect mice from lipopolysaccharide-mediated acute lung injury by inhibiting neutrophil elastase. J. Funct. Foods. 2017, 38:582-590. (SCI) (I.F.: 3.197; R/C=33/135 in FOOD SCIENCE & TECHNOLOGY)
16. Yao-Wen Chang, Ching-Ping Tseng, Chih-Hsun Lee, Tsong-Long Hwang, Yu-Li Chen, Mei-Tzu Su, Kowit-Yu Chong, Ying-Wei Lan, Chin-Chung Wu, Kung-Ju Chen, Fen-Hua Lu, Hsiang-Ruei Liao, Chuen Hsueh, Pei-Wen Hsieh*. β-Nitrostyrene derivatives attenuate LPS-mediated acute lung injury via the inhibition of neutrophil-platelet interactions and NET release. Am. J. Physiol. Lung Cell Mol. Physiol. 2018, 314:L654-L669. (SCI) (I.F.: 4.060; R/C=14/81 in PHYSIOLOGY)
17. Bidyadhar Sethy, Chung-Fan Hsieh, Chieh Yeh, Jim-Tong Horng, Pei-Wen Hsieh*. Design, synthesis and structure-activity relationships of a new class of anti-human enterovirus D68 and A71 agents. Future Med. Chem. 2018, 10:1333-1347. (SCI) (I.F.: 3.617; R/C=19/61 in CHEMISTRY, MEDICINAL)
18. 86.   Zih-Chan Lin, Pei-Wen Hsieh, Tsong-Long Hwang, Chi-Yuan Chen, Calvin T. Sung, Jia-You Fang. Topical application of anthranilate derivatives ameliorates psoriatic inflammation in a mouse model by inhibiting keratinocyte-derived chemokine expression and neutrophil infiltration. FASEB J. 2018, 32:6783-6795. (SCI) (I.F.: 5.391; R/C=8/87 in Biology)
19. Bidyadhar Sethy, Chung-Fan Hsieh, Ta-Jen Lin, Po-Yuan Hu, Yu-Li Chen, Chia-Yi Lin, Sung-Nain Tseng, Jim-Tong Horng*, Pei-Wen Hsieh*. Design, synthesis, and biological evaluation of itaconic acid derivatives as potential anti-influenza agents. J. Med. Chem. 2019, 62:2390-2403. (SCI) (I.F.: 6.054; R/C=3/61 in CHEMISTRY, MEDICINAL)
20. Nobuo Watanabe, Masako Kidokoro, Yusuke Suzuki, Makiko Tanaka, Shigeaki Inoue, Hideo Tsukamoto, Noriaki Hirayama, Pei-Wen Hsieh, Ching-Ping Tseng, Yoshihide Nakagawa, Sadaki Inokuchi. A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction. PLoS One 2019, 14: e0222331. (SCI) (I.F.: 2.776; R/C=24/69 in MULTIDISCIPLINARY SCIENCES)
21. Ching-Ping Tseng, Yu-Ling Huang, Yao-Wen Chang, Hsiang-Ruei Liao, Yu-Li Chen, Pei-Wen Hsieh*. Polysaccharide-containing fraction from Artemisia argyi inhibits tumor cell-induced platelet aggregation by blocking interaction of podoplanin with C-type lectin-like receptor 2. J. Food Drug Anal. 2019, 28:115-123. (SCI) (I.F.: 4.176; R/C=13/135 in FOOD SCIENCE & TECHNOLOGY)
22. Chung-Fan Hsieh, Jia-Rong Jheng, Guan-Hua LinYu-Li Chen, Jin-Yuan Ho, Chien-Jou Liu, Kuei-Yang Hsu, Yuan-Siao Chen, Yoke Fun Chan, Hui-Ming Yu, Pei-Wen Hsieh, Jyh-Haur Chern, Jim-Tong Horng. Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors. Emerg. Microbes Infec. 2020, 9:1194-1205. (SCI) (I.F.: 19.568; 7/136 in Microbiology)
23. Eman Al-Sayed, Michal Korinek, Ahmed Esmat, Guan-Yu Chen, Yuan-Bin Cheng, Pei-Wen Hsieh, Bing-Hung Chen, Tsong-Long Hwang*. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry 2020, 177:112429. (SCI) (I.F.: 4.004; 53/238 in PLANT SCIENCES)
24. Kung-Ju Chen, Yu-Li Chen, Shir-Hwa Ueng, Tsong-Long Hwang, Liang-Mou Kuo*, Pei-Wen Hsieh*. Neutrophil elastase inhibitor (MPH-966) improves intestinal mucosal damage and gut microbiota in a mouse model of 5-fluorouracil–induced intestinal mucositis. Biomed. Pharmacother. 2021, 134:111152. (SCI) (I.F.: 7.419; R/C=24/279 in PHARMACOLOGY & PHARMACY)
25. Michal Korinek, Pei-Shan Hsieh, Yu-Li Chen, Pei-Wen Hsieh, Shih-Hsin Chang, Yi-Hsiu Wu, Tsong-Long Hwang*. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem. Pharmacol. 2021, 190:114596. (SCI) (I.F.: 6.100; R/C=46/279 in PHARMACOLOGY & PHARMACY)
26. Che-Chuan Wang, Pei-Wen Hsieh, Jinn-Rung Kou, Su-Jane Wang*. Rosmarinic acid, a bioactive phenolic compound, inhibits glutamate release from rat cerebrocortical synaptosomes through GABAA receptor activation. Biomolecules 2021, 11:1029. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
27. Hao-Wei Chu, Bidyadhar Sethy, Pei-Wen Hsieh, Jim-Tong Horng*. Identification of potential drug targets of broad-spectrum inhibitors with a Michael acceptor moiety using shotgun proteomics. Viruses 2021, 13:1756. (SCI) (I.F.: 5.818; 14/37 in VIROLOGY)
28. Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang*. Natural product isoliquiritigenin activates GABAB receptors to decrease voltage-gate Ca2+ channels and glutamate release in rat cerebrocortical nerve terminals. Biomolecules 2021, 11:1537. (SCI) (I.F.: 6.064; R/C=75/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
29. Anna Chang, Chi-Feng Hung, Pei-Wen Hsieh, Horng-Huey Ko and Su-Jane Wang*. Eupafolin suppresses P/Q-Type Ca2+ channels to inhibit Ca2+/ calmodulin-dependent protein kinase II and glutamate release at rat cerebrocortical nerve terminals. Biomol. Ther. (Seoul) 2021, 29:630-636. (SCI) (I.F.: 4.231; R/C=106/279 in PHARMACOLOGY & PHARMACY)
30. Yi-Chieh Hung, Yi-Hsiu Kuo, Pei-Wen Hsieh, Ting-Yang Hsieh, Jinn-Rung Kuo, Su-Jane Wang*. Chlorogenic acid decreases glutamate release from rat cortical nerve terminals by P/Q-type Ca2+ channel suppression: a possible neuroprotective mechanism. Int. J. Mol. Sci. 2021, 22:11447. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
31. Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin*, Su-Jane Wang*. An anthranilate derivative inhibits glutamate release and glutamate excitotoxicity in rats. Int. J. Mol. Sci. 2022, 23:2641. (SCI) (I.F.: 6.208; R/C=69/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY)
32. Chung-Fan Hsieh, Yu-Li Chen, Guan-Hua Lin, Yoke Fun Chan, Pei-Wen Hsieh, and Jim-Tong Horng*. 3,4-Dicaffeoylquinic acid from the medicinal plant Ilex kaushue disrupts the interaction between the five-fold axis of enterovirus A-71 and the heparan sulfate receptor. J. Virol. 2022, 96: e0054221. (SCI) (I.F.: 6.549; 11/37 in VIROLOGY)
33. Kung-Ju Chen, Yu-Ling Huang, Liang-Mou Kuo, Yi-Ting Chen, Chi-Feng Hung, Pei-Wen Hsieh*. Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: impact on inflammation and gut microbiota dysbiosis. Phytomedicine 2022, 101:154092. (SCI) (I.F.: 6.656; R/C=1/30 in INTEGRATIVE & COMPLEMENTARY MEDICINE)