Jump to the main content block

Molecular Genetics Laboratory

Dr.Chin-Chuan Chen

Position:Associate Professor

pic

Degree: Ph.D.

Graduated from: University of Colorado Health Sciences Center, U.S.A.

Laboratory: Molecular Genetics

E-MAIL: chinchuan@mail.cgu.edu.tw

Phone: +886-3-2118800 ext 3719

Research Interests: 

 
1. DNA repair, genome stability and cancer
2. Aging and aging-associated diseases

Selected Publications:

  1. Chen CC, Li HY4, Leu YL, Chen YJ, Wang CJ, Wang SH. Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and Reduces Atherosclerosis in ApoE-Deficient Mice. (2020) Antioxidants 25;9(4) doi: 10.3390/antiox9040275
  2. Wang TH, Chen CC(co-first), Huang KY, Shih YM, Chen CY. High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. (2019) Phytomedicine 64:152926. doi: 10.1016/j.phymed.2019.152926
  3. Kuo CH, Leu YL, Wang TH, Tseng WC, Feng CH, Wang SH, Chen CC*. A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels. (2019) DNA repair 82:102690 doi: 10.1016/j.dnarep.2019.102690
  4. Chen CC, Lee TY, Leu YL, Wang SH. Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. (2019) Translational Research. 210:26-42 doi: 10.1016/j.trsl.2019.04.006
  5. Wang TH, Chen CC (co-first), Hsiao YC, Lin YH, Pi WC, Huang PR, Wang TV, Chen CY. Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. (2019) Cancers (Basel). 8;11(3)
  6. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. (2018) Cancers (Basel). 10;10(9)
  7. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. (2018) Cell Death Dis. 1;9(5):543
  8. Huang TH, Fowler F, Chen CC, Shen ZJ, Sleckman B, Tyler JK. The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. (2018) Mol Cell. 1;69(5):879-892.e5. doi: 10.1016/j.molcel
  9. Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, Wu JC, Chen CC*. Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. (2015) PLoS One. 10(7):e0134110. doi: 10.1371/journal.pone.0134110
  10. Chen, C-C., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger, J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of double-strand DNA repair. (2008) Cell, 134, 231-43.

Patents:

  1. 陳金銓,呂彥禮,黃聰龍,方嘉佑,潘台龍 ACTIVATOR OF MAMMALIAN SIRT1 中華民國專利1556818 (2016)
  2. 陳金銓,呂彥禮,王淑慧哺乳類TOR抑制劑中華民國I 586351 (2017)
  3. 陳金銓,呂彥禮,王淑慧哺乳類TOR抑制劑美國US 9,795,588 B2 (2017)

實驗室生活照:

Departmental Retreat 2014

pic

Farewell party 2014

pic

Farewell party 2015 pic

Birthday party 2015

pic

Farewell party 2016

pic

Departmental Retreat 2016

pic

Departmental Retreat 2017

pic

Lab Farewell party 2017

pic

Lab Farewell party 2018

pic

Lab Farewell party 2019

pic

Lab New year party 2020

pic