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Molecular Genetics Laboratory

Dr.Chin-Chuan Chen

Position:Associate Professor

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Degree: Ph.D.

Graduated from: University of Colorado Health Sciences Center, U.S.A.

Laboratory: Molecular Genetics

E-MAIL: chinchuan@mail.cgu.edu.tw

Phone: +886-3-2118800 ext 3719

Research Interests: 

 
1. DNA repair, genome stability and cancer
2. Aging and aging-associated diseases

Selected Publications:

1. Wang TH., Tseng WC., Leu YL., Chen CY., Lee WC., Chi YC., Cheng SF., Lai CY., Kuo CH., Yang SL., Yang SH., Shen JJ., Feng CH., Wu CC., Hwang TL., Wang CJ., Wang SH., Chen CC*. The flavonoid corylin exhibits lifespan extension properties in mouse. (2022) Nature communications doi:10.1038/s41467-022-28908-2

2. Chen CC, Chen CY, Cheng SF, Shieh TM, Leu YL, Chuang WY, Liu KT, Ueng SH, Shih YH, Chou LF, Wang TH. Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models. (2021) Int J Mol Sci. 9;22(18):9766. doi: 10.3390/ijms22189766

3. Wang TH, Chen CC(co-first), Leu YL, Lee YS, Lian JH, Hsieh HL, Chen CY. Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma. (2021) J Formos Med Assoc.18:S0929-6646(20)30609-4. doi: 10.1016/j.jfma.2020.12.009

4. Tseng WC, Chen CY, Chern CY, Wang CA, Lee WC, Chi YC, Cheng SF, Kuo YT, Chiu YC, Tseng ST, Lin PY, Liou SJ, Li YC, Chen CC*. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. (2021) Int J Mol Sci. Apr 23;22(9):4422. doi: 10.3390/ijms22094422.

5. Chen CC, Kuo CH, Leu YL, Wang SH. Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation. (2021) Pharmacol Res. 27:105291. doi: 10.1016/j.phrs.2020.105291

6. Chen CY, Fang JY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Wei LS, Cheng SF, Hsueh C, Wang TH. 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression. (2020) Frontiers in Oncology 10:1319. doi: 10.3389/fonc.2020.01319

7. Chen CY, Chen CC(co-first), Chuang WY, Leu YL, Ueng SH, Hsueh C, Yeh CT, Wang TH. Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. (2020) Frontiers in Oncology 25;10:216. doi: 10.3389 /fonc.2020.00216

8. Chen CC, Li HY, Leu YL, Chen YJ, Wang CJ, Wang SH. Corylin Inhibits Vascular Cell Inflammation, Proliferation and Migration and Reduces Atherosclerosis in ApoE-Deficient Mice. (2020) Antioxidants 25;9(4) doi: 10.3390/antiox9040275

9. Wang TH, Chen CC(co-first), Huang KY, Shih YM, Chen CY. High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells. (2019) Phytomedicine 64:152926. doi: 10.1016/j.phymed.2019.152926

10. Kuo CH, Leu YL, Wang TH, Tseng WC, Feng CH, Wang SH, Chen CC*. A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels. (2019) DNA repair 82:102690 doi: 10.1016/j.dnarep.2019.102690

11. Chen CC, Lee TY, Leu YL, Wang SH. Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1 adipocytes and protects against high-fat diet-induced obesity and metabolic disorders in mice. (2019) Translational Research. 210:26-42 doi: 10.1016/j.trsl.2019.04.006

12. Wang TH, Chen CC (co-first), Hsiao YC, Lin YH, Pi WC, Huang PR, Wang TV, Chen CY. Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres. (2019) Cancers (Basel). 8;11(3) doi: 10.3390/cancers11030334

13. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. (2018) Cancers (Basel). 10;10(9) DOI: 10.3390/cancers10090320

14. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. (2018) Cell Death Dis. 1;9(5):543

15. Huang TH, Fowler F, Chen CC, Shen ZJ, Sleckman B, Tyler JK. The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells. (2018) Mol Cell. 1;69(5):879-892.e5. doi: 10.1016/j.molcel.2018.01.031

16. Chen CC, Huang JS, Wang TH, Kuo CH, Wang CJ, Wang SH, Leu YL. Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52. (2017) Int J Mol Sci. 18(12),2655. doi: 10.3390/ijms18122655

17. Yeh CJ, Chen CC (co-first), Leu YL, Lin MW, Chiu MM, Wang SH. The effects of artocarpin on wound healing: in vitro and in vivo studies. (2017) Scientific reports; 7(1):15599. doi: 10.1038/s41598-017-15876-7

18. Chen CC, Liang CJ, Leu YL, Chen YL, Wang SH. Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo. (2016) PLoS one 11(12): e0168092. doi:10.1371/journal.pone.0168092

19. Chen CC, Lin MW, Liang CJ, Wang SH. The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. (2016) PLoS One. 11(7):e0158662. doi: 10.1371/journal.pone.0158662

20. Wang SH, Lin PY, Chiu YC, Huang JS, Kuo YT, Wu JC, Chen CC*. Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. (2015) PLoS One. 10(7):e0134110. doi: 10.1371/journal.pone.0134110

21. Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK. Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging. (2014) Genes & Development, 15;28(4):396-408 DOI: 10.1101/gad.233221.113

22. Chen CC. & Tyler, J. K. Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. (2009) Cell Cycle 8(18).

23. Chen CC. & Tyler, J. K. Chromatin assembly signals the end of repair. (2008) Cell Cycle, 7, 3792-7.

24. Chen CC., Carson, J., Feser, J., Tamburini, B., Zabaronick, S., Linger, J. & Tyler, J. K. Acetylation of lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of double-strand DNA repair. (2008) Cell, 134, 231-43. OI: 10.1016/j.cell.2008.06.035

Patents:

  1. 陳金銓,呂彥禮,黃聰龍,方嘉佑,潘台龍 ACTIVATOR OF MAMMALIAN SIRT1 中華民國專利1556818 (2016)
  2. 陳金銓,呂彥禮,王淑慧哺乳類TOR抑制劑中華民國I 586351 (2017)
  3. 陳金銓,呂彥禮,王淑慧哺乳類TOR抑制劑美國US 9,795,588 B2 (2017)

實驗室生活照:

Departmental Retreat 2014

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Farewell party 2014

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Farewell party 2015 pic

Birthday party 2015

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Farewell party 2016

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Departmental Retreat 2016

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Departmental Retreat 2017

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Lab Farewell party 2017

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Lab Farewell party 2018

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Lab Farewell party 2019

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Lab New year party 2020

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Lab party 2021

Lab Farewell party 2022